October 2018, Paper acceptedWe are looking for multiple Phd students to work on big data projects on developing new algorithms and software for high-dimensional neural datasets. Come join vibrant lab with experimental and theoretical work in Germany's neuroscience hub! Also looking for master students. See Jobs.
We used optogenetics and electrophysiology to record from specific GABAergic interneurons in the hippocampus before and during epileptic seizures. The hippocampus is the main focus where seizures originate, and inhibition is thought to play a critical role in the generation of epileptic seizures. The reason for this is that inhibition plays a critical role in stabilizing network dynamics and balancing recurrent excitatory activity. We used optogenetics to identify specific identified GABAergic interneurons, and tracked their activity before and during seizures. Surprisingly, we found a very strong increase in the firing of a specific interneuron (PV interneuron) right before the seizure. In addition, we found that their activity becomes decoupled from the excitatory cell activity. These PV interneurons are thought to play a critical role in network stabilization. These data suggest that an increase in their activity together with decoupling from excitatory neurons could cause
the destabilization of network activity and epileptic seizures.
September 2018My old colleague Jeroen Bos got his PhD at the University of Amsterdam. Congratulations, Jeroen! It was great fun working together with you. Any lab will be lucky to have Jeroen for postdoc. Jeroen's thesis (some parts under embargo) can be found at the UvA website. Including some nice unpublished work we did together on how the brain represents other agents.
Our postdoc Ana made some beautiful simultaneous recordings from multiple areas and layers together with optogenetics.. And PhD student Irene tagging multiple SOM interneurons.with optogenetics.
We will be at Bernstein Computational Neuroscience Meeting in Berlin. Cem is presenting. Fantastic workshops this year. Very interesting predictive coding session, good to see these ideas are still alive and relevant.
Also amazing talk from James DiCarlo. Lots of cool development in recurrent neural networks.
Peter, A.*, Uran, C*, Klon-Lipok, J, Roese, R., van Stijn, S., Barnes, W., Dowdall, J, Singer, W, Fries, P, Vinck, M. Surface color and predictability determine contextual modulation of V1 firing and gamma oscillations. 2018. Biorxiv
Result of a great collaboration with Fries and Singer labs, and amazing PhD students Alina and Cem. Six different nationalities on this paper, and some generation mixing.
We had a great "ESI-Sync 2018" meeting. Thanks Miriam, Ana, Maestro Andre and Nina. http://www.esi-frankfurt.de/esisync/ I especially enjoyed Floris de Lange's talk, a creative thinker with great conceptual depth, and I was impressed what he extracts from neuroimaging methods! Keep an eye on 2019!
Batista-Brito*, R, Zagha*, E, Ratliff, J., Vinck, M*. Modulation of cortical circuits by top-down processing and arousal state in health and disease. Current Opinion in Neurobiology.
Paper with some good old friends from the Yale and gpscy times. Interneuron mechanisms of top-down attention and state modulation and how it might be messed up in psychiatric diseases like schizophrenia.
Grossberger, L., Battaglia, F., Vinck, M. Unsupervised clustering of temporal patterns in high-dimensional neuronal ensembles using a novel dissimilarity measure. PLOS Computational Biology.
Amazing work from master student Lukas, and long collaboration with Fra. Too bad Lukas declined IMPRS offer and got hired by Bosch Machine Learning group...but he will build some pretty mean machines :)
Pesaran, B. Vinck, M., Einevoll, G., Sirota, A., Fries, P., Siegel, M., Truccolo, W., Schroeder, C., Srinivasan, R. 2018. Investigating large-scale brain dynamics using field potential recordings: Analysis and interpretation. Nature Neuroscience
Useful piece for advanced graduate students who wants to learn more about interpreting and analyzing brain data. Thanks to Bijan for organizing this and giving room to many voices.